SYSTANE PRO Preservative-Free
With science this advanced, it’s a simple choice
Behind every drop is 20 years of dry eye research, resulting in our most comprehensive, long-lasting formula yet.
Make a simple choice with SYSTANE® PRO PF
The preservative-free triple-action formula hydrates, restores, and protects dry eyes.
Up to 12 hours of dry eye relief*
For all types of dry eye: aqueous, evaporative, mixed
Preservative-free
Contact lens friendly†
With up to 12 hours of dry eye relief* patients may dose as little as twice a day, fitting SYSTANE® PRO PF by Alcon seamlessly into their daily routine.
Why ECPs choose SYSTANE® PRO PF
Dr. Jennifer Harthan, OD, FAAO, FSLS*
Glenview Vision Care, Glenview, IL
“One of the things I love about SYSTANE® PRO PF is...it’s suitable for all patients with all types of dry eye...so you don’t have to think, is this artificial tear good for this person?”
Dr. Douglas Devries, OD*
Eye Care Associates of Nevada, Sparks, Nevada
“Patients have busy lifestyles. To have a formulation that’s going to last up to 12 hours†—that’s the difference between getting through your workday and not getting through your workday.”
*Dr. Jennifer Harthan and Dr. Douglas Devries are paid consultants for Alcon.
†47% of patients experience meaningful symptom relief at 12 hours (n=153).
Witness the evolution of ocular surface science
See how SYSTANE® PRO Preservative-Free works: Supporting the active ingredient propylene glycol, the HP-Guar meshwork, lipid nanodroplets, and hyaluronate work together to hydrate, restore, and protect1-7—providing dry eye relief for up to 12 hours.*
Propylene Glycol
The active ingredient that lubricates and soothes dry eyes.1
HP-Guar
HP-Guar and borate ions cross-link to form a gel-like meshwork that mimics the tear film’s mucin layer and enhances its thickness, supporting the healing of the corneal epithelial cells and lowering tear osmolarity.2,3,6†
Phospholipid Nanoemulsion
Optimizes the coverage area of phospholipids to reduce tear evaporation and enhance tear film stability.7‡
Hyaluronate
A naturally occurring “moisture magnet” that helps the lubricant provide long-lasting hydration.5§
The difference is in the data
A clinical study demonstrated that SYSTANE® PRO Preservative-Free delivers across 3 key measures of dry eye relief to hydrate, restore, and protect all types of dry eye.
Hydrates
84% of subjects strongly agreed or agreed that their eyes felt hydrated immediately after SYSTANE® PRO PF instillation.8
Restores
Non-invasive tear breakup time (NITBUT) significantly improved from baseline on Day 1 and Day 30, demonstrating tear film stability improvement.9
Protects
Dry Eye Symptoms (DES) scores significantly improved vs. baseline at 12 hours after instillation.10*
See how SYSTANE® PRO PF hydrates, restores, and protects below:
Hydrates
84% of subjects strongly agreed or agreed that their eyes felt hydrated1*†
*Based on a Phase 3, single-arm, open-label, multicenter study in which subjects with dry eye disease instilled at least 1 drop of SYSTANE® PRO PF into each eye at least 4 times daily for 30 days; n=158.
†Responded “Strongly agree” or “Agree” to the Likert question, “Do your eyes feel hydrated?,” immediately after SYSTANE® PRO PF instillation.
Reference: 1. Alcon data on file, 2025.
Restores
NITBUT significantly improved from baseline on Days 1 and 301*
*Based on a Phase 3, single-arm, open-label, multicenter study in which subjects with dry eye disease instilled at least 1 drop of SYSTANE® PRO PF into each eye at least 4 times daily for ~30 days; n=158. The mean change from baseline on Day 1 or Day 30 did not meet the established threshold for clinically meaningful change of 2.5 seconds; P<0.0001.
Reference: 1. Alcon data on file, 2025.
Protects
Statistically significant improvement in DES Score following a single drop of SYSTANE® PRO PF in each eye, even up to 12 hours1*†
*Based on a Phase 3, single-arm, open-label, multicenter study in which subjects with dry eye disease instilled at least 1 drop of SYSTANE® PRO PF into each eye at least 4 times daily for 30 days; n=158.
†P<0.0001 vs. baseline; DES, Dry Eye Symptoms.
Reference: 1. Alcon data on file, 2025.
How SYSTANE® PRO PF compares
*47% of patients experience meaningful symptom relief at 12 hours (n=153).
†Based on label claim or publicly available promotional materials for Refresh Optive Mega-3, Blink Triple Care, and iVizia for dry eyes.
^Trademarks are the property of their respective owners.
*Based on in vitro measurements.
^Trademarks are the property of their respective owners.
Patient savings
Help your patients try SYSTANE® PRO Preservative-Free. Sign up to order coupons sent directly to your office.
A clearer path to diagnosing dry eye disease (DED)
DED can present in different ways, making diagnosis less straightforward. Released by the Tear Film & Ocular Surface Society (TFOS), the TFOS Dry Eye Workshop (DEWS) III recommendations outline a path from patient history and symptom screening to clinical evaluation.12
Patient history + risk factors → Symptom screening → Homeostasis marker testing
ASK THE RIGHT QUESTIONS
Assess symptoms, triggers, visual fluctuation, discomfort, and relevant risk factors.12
SCREEN SYMPTOM BURDEN
Use OSDI-6 to help identify patients whose symptoms may point to dry eye disease.12,13
EVALUATE CLINICAL SIGNS
Confirm with homeostasis markers, such as tear breakup time, osmolarity, and ocular surface staining.12
Looking for more dry eye disease resources?
Explore additional educational tools and videos from the World Council of Optometry, presented in partnership with Alcon, including resources informed by TFOS DEWS III guidance.
Dry eye relief starts with choosing the right artificial tear
Artificial tears are a cornerstone of dry eye treatment. Choosing the right one depends on several key factors—from the patient’s dry eye type and symptom presentation to frequency of use and contact lens compatibility.13
SYSTANE® PRO PF is:
Preservative-free Long-lasting dry eye relief For all types of dry eye: aqueous, evaporative, mixed presentation Contact lens friendly*
Formulated to hydrate, restore, protect, and provide up to 12 hours† of dry eye relief, SYSTANE® PRO PF is a simple choice.
*Not a rewetting drop.
†47% of patients experience meaningful symptom relief at 12 hours (n=153).
Why SYSTANE®?
As part of Alcon's #1 doctor recommended family of brands,* SYSTANE® offers a range of formulas that provide real, long-lasting relief for patients with all types of dry eye.
*Based on IQVIA ProVoice Survey of Eye Care Professionals, 12 months ending December 31, 2025.
1. FDA - OTC Ophthalmic Monograph M018: April 2022.
2. Kesavan S, et al. Macromolecules. 1992;25(7):2026-2032.
3. Ubels JL, et al. Curr Eye Res. 2004;28(6):437-444.
4. Rangarajan R, et al. J Ocul Pharmacol Ther. 2019;35(1):32-37.
5. Rangarajan R, et al. J Ocul Pharmacol Ther. 2015;31(8):491-497.
6. Ng A, et al. Clin Ophthalmol. 2018;12:695-700.
7. Moon SW, et al. Cornea. 2010;29(12):1430-1435.
8. Alcon data on file, 2025.
9. Alcon data on file, 2025.
10. Alcon data on file, 2025.
11. Alcon data on file, 2024.
12. Wolffsohn JS, et al. TFOS DEWS III: Diagnostic Methodology. Am J Ophthalmol. 2025;279:387-450. doi:10.1016/j.ajo.2025.05.033
13. Pult H, Wolffsohn JS. Ocul Surf. 2019;17(4):817-821.
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