* Defined as Modified Miyata grade 0, <25mv/mm2 over 3 years (n=138), and over 9 years (n=20), respectively.
† Trademarks are the property of their respective owners.
†† Compared in vitro with TECNIS† OptiBlue† ZCB00V, TECNIS† ZCB00, Vivinex† XY-1, Eternity† Natural Uni W-60, and enVista† MX60. (Surface haze and SSNGs: n=10 lenses per group, P<0.001; glistenings: n=30 IOLs per group, P<0.001.)
‡ In an additional analysis, 98.4% of Clareon® IOLs (n=127 ) had an absolute rotation of ≤10° between surgery and 6 months.
‡‡ Mean rotation at day 1 (n=127 ) and 6 months (n=124 ): 1 .8° ± 3 .7° and 2 .3° ± 3 .9°, respectively. Study measures were taken at baseline (immediately after surgery, <1 hour ), at day 1, and at months 1, 3, and 6.
§ Prospective, randomized, unmasked clinical study of the AcrySof® IQ ReSTOR® +3.0 D Toric Multifocal IOL (Models SND1T3-SND1T6) in first eye vs. ReSTOR® +4.0 D Multifocal IOL in the second eye. Primary objective was to determine non-inferiority of ReSTOR® +3.0 D Toric Multifocal IOL to ReSTOR +4.0 D Multifocal IOL for UCDVA and UCNVA at fixed distances for first eye at 12 months.
§§ Post-hoc analysis to confirm that IOLs maintained rotational stability between visit 3 (1-month post-op) and visit 4 (6-months post-op).
¶ Mean absolute difference between achieved lens axis at surgery and visit 5 (12 months), ±5.8˚.
¶¶ AstigmatismFix.com is an online calculator to help surgeons determine if a previously placed toric IOL is ideally aligned. The analysis dataset includes 5,674 entries, with each unique lens and intended orientation identified, in addition to postoperative IOL orientation. ≥ 5° from intended axis. The dataset was weighted based on the estimated market usage of each lens. The full evaluation included AcrySof® IQ Toric, TECNIS† Toric, Trulign† Toric and Staar† Toric IOLs.
‖ Clareon® and AcrySof® share the same aspheric design.
IMPORTANT PRODUCT INFORMATION: CLAREON® FAMILY OF IOLS
CAUTION: Federal law restricts these devices to sale by or on the order of a physician.
INDICATIONS: The family of Clareon® intraocular lenses (IOLs) includes the Clareon® Aspheric Hydrophobic Acrylic and Clareon® Aspheric Toric IOLs, the Clareon® PanOptix® Trifocal Hydrophobic IOL, Clareon® PanOptix® Toric, Clareon® Vivity® Extended Vision Hydrophobic Posterior Chamber IOL and Clareon® Vivity® Toric IOLs. Each of these IOLs is indicated for visual correction of aphakia in adult patients following cataract surgery. In addition, the Clareon® Toric IOLs are indicated to correct pre-existing corneal astigmatism at the time of cataract surgery. The Clareon® PanOptix® lens mitigates the effects of presbyopia by providing improved intermediate and near visual acuity, while maintaining comparable distance visual acuity with a reduced need for eyeglasses, compared to a monofocal IOL. The Clareon® Vivity® lens mitigates the effects of presbyopia by providing an extended depth of focus. Compared to an aspheric monofocal IOL, the lens provides improved intermediate and near visual acuity, while maintaining comparable distance visual acuity. All of these IOLs are intended for placement in the capsular bag.
General cautions for all Clareon® IOLs:
Careful preoperative evaluation and sound clinical judgment should be used by the surgeon to decide the risk/benefit ratio before implanting any IOL in a patient with any of the conditions described in the Directions for Use that accompany each IOL. Physicians should target emmetropia, and ensure that IOL centration is achieved.
For the Clareon® Aspheric Toric, PanOptix® Toric and Vivity® Toric IOLs, the lens should not be implanted if the posterior capsule is ruptured, if the zonules are damaged, or if a primary posterior capsulotomy is planned. Rotation can reduce astigmatic correction; if necessary lens repositioning should occur as early as possible prior to lens encapsulation.
For the Clareon® PanOptix® IOL, some visual effects may be expected due to the superposition of focused and unfocused multiple images. These may include some perceptions of halos or starbursts, as well as other visual symptoms. As with other multifocal IOLs, there is a possibility that visual symptoms may be significant enough that the patient will request explant of the multifocal IOL. A reduction in contrast sensitivity as compared to a monofocal IOL may be experienced by some patients and may be more prevalent in low lighting conditions. Therefore, patients implanted with multifocal IOLs should exercise caution when driving at night or in poor visibility conditions. Patients should be advised that unexpected outcomes could lead to continued spectacle dependence or the need for secondary surgical intervention (e.g., intraocular lens replacement or repositioning). As with other multifocal IOLs, patients may need glasses when reading small print or looking at small objects. Posterior capsule opacification (PCO), may significantly affect the vision of patients with multifocal IOLs sooner in its progression than patients with monofocal IOLs.
For the Clareon® Vivity® IOL, most patients implanted with the Vivity® IOL are likely to experience significant loss of contrast sensitivity as compared to a monofocal IOL. Therefore, it is essential that prospective patients be fully informed of this risk before giving their consent for implantation of the Clareon® Vivity® IOL. In addition, patients should be warned that they will need to exercise caution when engaging in activities that require good vision in dimly lit environments, such as driving at night or in poor visibility conditions, especially in the presence of oncoming traffic. It is possible to experience very bothersome visual disturbances, significant enough that the patient could request explant of the IOL. In the parent AcrySof® IQ Vivity® IOL clinical study, 1% to 2% of AcrySof® IQ Vivity® IOL patients reported very bothersome starbursts, halos, blurred vision, or dark area visual disturbances; however, no explants were reported.
Prior to surgery, physicians should provide prospective patients with a copy of the Patient Information Brochure available from Alcon informing them of possible risks and benefits associated with these IOLs.
ATTENTION: Reference the Directions for Use labeling for each IOL for a complete listing of indications, warnings and precautions.
- Clareon® Toric Directions for Use.
- Werner L, Thatthamla I, Ong M, et al. Evaluation of clarity characteristics in a new hydrophobic acrylic IOL. J Cataract Refract Surg. 2019;45:1490-1497.
- Oshika T, Fujita Y, Inamura M, Miyata K. Mid-term and long-term clinical assessments of a new 1-piece hydrophobic acrylic IOL with hydroxyethyl methacrylate. J Cataract Refract Surg. 2020 May;46(5):682-687.
- Maxwell A, Suryakumar R. Long-term effectiveness and safety of a three-piece acrylic hydrophobic intraocular lens modified with hydroxyethyl-methacrylate: an open-label, 3-year follow-up study. Clin Ophthalmol. 2018;12:2031-2037.
- Lehmann R, Maxwell A, Lubeck DM, Fong R, Walters TR, Fakadej A. Effectiveness and Safety of the Clareon® Monofocal Intraocular Lens: Outcomes from a 12-Month Single-Arm Clinical Study in a Large Sample. Clin Ophthalmol. 2021;15:1647-1657. Published 2021 Apr 20.
- Alcon Data on File, 2017.
- Lane S, Collins S, Das KK, Maass S, Thatthamla I, Schatz H, Van Noy S, Jain R. Evaluation of intraocular lens mechanical stability. J Cataract Refract Surg. 2019 Apr;45(4):501-506.
- Alcon Data on File, 2020.
- Potvin R, Kramer BA, Hardten DR, Berdahl JP. Toric intraocular lens orientation and residual refractive astigmatism: an analysis. Clin Ophthalmol. 2016;10:1829-1836.
- Oshika, Tetsuro, et al. Comparison of incidence of repositioning surgery to correct misalignment with three toric intraocular lenses. Eur J Ophthalmol. 2019. doi: 10.1177/1120672119834469.
- Lee B, Chang D. Comparison of the rotational stability of two toric intraocular lenses in 1273 consecutive eyes. Ophthalmology. 2018;125(9):1325-1331.
- Bala, Chandra, et al. Multi-country clinical outcomes of a new nondiffractive presbyopia-correcting intraocular lens. Journal of Cataract and Refractive Surgery Publish Ahead of Print DOI: 10.1097/j.jcrs.0000000000000712.
- Varma, Devesh, et al. Clinical Outcomes of a New Non-Diffractive Presbyopia-Correcting Intraocular Lens From Two Large Confirmatory Studies. American Academy of Opthalmology. Abstract: PA005.
- Clareon® Vivity® Directions for Use.
- Clareon® PanOptix® Trifocal Hydrophobic Acrylic IOL Directions for Use.