Clearly Different

Certain clinical situations place undue stress on the corneal endothelium, retina and other ocular structures. BSS PLUS® Sterile Intraocular Irrigating Solution combines an energy source, a buffer and an antioxidant to maximally protect and nourish the health of intraocular tissues.

Cataract Extraction See More

During phacoemulsification BSS PLUS® Solution protects the endothelium by minimizing pleomorphism during short and long term irrigation of the anterior chamber.1

Post IOL Implantation
After the IOL has been implemented in the capsular bag and after viscoelastic devices are removed, BSS PLUS® Solution continues to provide physiologic support to the corneal endothelium.

Protecting the Corneal Endothelium
Glutathione maintains the junctional complexes of corneal endothelial cells2 and protects the integrity of the blood-aqueous barrier.3 Ocular tissue is highly sensitive to depletion of cellular glutathione can result in cell apoptosis.4 BSS PLUS® Solution has the ability to deliver a continuous supply of glutathione to the surgical site.

Post IOL Implantation
Cataract extraction procedures cause cellular morphologic changes post-operatively which are indicative of stressed endothelial and is associated with less corneal swelling and a higher percentage of hexagonal cells at two and seven days post-operatively.1

After cataract surgery, BSS PLUS® Solution is used to reform the anterior change and remains in the eye for up to eight hours. BSS PLUS® Solution provides nutrients, protection and a stable environment while the ciliary body generates and replaces BSS PLUS® Solution with natural aqueous humor.5

Cataract extraction

Vitreoretinal Disorders and Diseases See More

Vitreoretinal disease states can be accompanied by dramatic visual loss and complicated surgical procedures. BSS PLUS® Solution ensures that ocular tissues are protected from atmosphere and microscope light exposure as well as metabolic stress from free-radical formation.

BSS PLUS® Solution remains in the posterior of the eye even longer than the anterior chamber. Aqueous humor is generated during this time and replaces BSS PLUS® Solution.

Vitreoretinal surgery
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Important information about BSS PLUS® Irrigating Solution

Description: BSS PLUS® a sterile intraocular irrigating solution is used during all intraocular surgical procedures, including those requiring a relatively long intraocular perfusion time (e.g., pars plana vitrectomy, phacoemulsification, extracapsular cataract extraction/lens aspiration, anterior segment reconstruction, etc.). The solution does not contain a preservative and should be prepared just prior to use in surgery.

Indications and Usage: BSS PLUS® Irrigating Solution is indicated for use as an intraocular irrigating solution during intraocular surgical procedures involving perfusion of the eye.

Contraindications: There are no specific contraindications to the use of BSS PLUS® Irrigating Solution; however, contraindications for the surgical procedure during which BSS PLUS® Irrigating Solution is to be used should be strictly adhered to.

Warnings: For IRRIGATION during ophthalmic surgery only. Not for injection or intravenous infusion. Do not use unless product is clear, seal is intact, vacuum is present and container is undamaged. Do not use if product is discolored or contains a precipitate.

Precautions: DO NOT USE BSS PLUS® IRRIGATING SOLUTION UNTIL PART I IS FULLY RECONSTITUTED WITH PART II. Discard unused contents. BSS PLUS® Irrigating Solution does not contain a preservative; therefore, do not use this container for more than one patient. Do not use additives other than BSS PLUS® Irrigating Solution Concentrate Part II (20 mL) with this product. Tissue damage could result if other drugs are added to product. DISCARD ANY UNUSED PORTION SIX HOURS AFTER PREPARATION. Studies suggest that intraocular irrigating solutions which are iso-osmotic with normal aqueous fluids should be used with caution in diabetic patients undergoing vitrectomy since intraoperative lens changes have been observed. There have been reports of corneal clouding or edema following ocular surgery in which BSS PLUS® Irrigating Solution was used as an irrigating solution. As in all surgical procedures appropriate measures should be taken to minimize trauma to the cornea and other ocular tissues.

Geriatric Use: No overall differences in safety or effectiveness have been observed between elderly and younger patients.

Adverse Reactions: Postoperative inflammatory reactions as well as incidents of corneal edema and corneal decompensation have been reported. Their relationship to the use of BSS PLUS® Irrigating Solution has not been established.

Overdosage: The solution has no pharmacological action and thus no potential for overdosage. However, as with any intraocular surgical procedure, the duration of intraocular manipulation should be kept to a minimum.