OPTI-FREE® PureMoist® Multi-Purpose Disinfecting Solution

Allows patients to wear contant lenses more comfortably1 and longer each day2

OPTI-FREE® PureMoist® Multi-Purpose Disinfecting Solution

HydraGlyde® Moisture Matrix

HydraGlyde® Moistue Matrix helps provide comfort from morning ‘til night.1-3

HydraGlyde® Moisture Matrix

POLYQUAD®/ALDOX® preservatives See more

Dependable disinfection when tested in vitro in the presence of a lens.

In 2012, the FDA sponsored a series of studies to show the impact different lens materials have on the concentration and efficacy of disinfectant in tested multipurpose solutions.

Biocidal Efficacy of POLYQUAD®/ALDOX® Preservatives Against Staphylococcus aureus4†

Objectives: This study examined the interaction of seven different lens materials with a multipurpose solution (MPS) containing the disinfectants polyquaternium-1 (0.001%) and myristamoidopropyl dimethylamine (0.0005%). The objective of this study was to determine whether the different lens materials affect the concentration of a disinfectant against Staphylococcus aureus.

Methods: Silicone hydrogel lenses (galyfilcon A, senofilcon A, comfilcon A, enfilcon A, balafilcon A, and lotrafilcon B) and a conventional hydrogel lens (etafilcon A) were soaked in polypropylene lens cases filled with commercially available MPS containing 0.001% polyquaternium-1 and 0.0005% myristamidopropyl dimethylamine for 6, 12, 24, 72, and 168 hours. Empty lens cases containing the seven types of lenses and controls were assayed for activity against S. aureus according to International Standards Organization 14729 standard with modifications. Test solutions were analyzed for polyquaternium-1 and myristamidopropyl dimethylamine concentration at each time point.

corneal staining comparison
 
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Tested a polyquaternium-1 and myristamidopropyl solution against Staphylococcus aureus:

  • "The concentration of polyquaternium-1 and myristamidoproply dimethylamine remaining in the lens case was reduced only slightly over time. Storage with the lenses did not adversely affect biocidal efficacy of the solution, and in some cases, it was significantly better (p=0.0029)."

Biocidal Efficacy of PHMB Against Fusarium solani5†

Objectives: To investigate the effects of eight different soft contact lenses on disinfection efficacy of a multipurpose solution (MPS) containing poly-hexamethylene biguanide (PHMB, 0.0001%, 6-hour soak) against Fusarium solani.

Methods: Six silicone hydrogel lenses (galyfilcon A, senofilcon A, comfilcon A, enfilcon A, balafilcon A, and lotrifilcon B) and two conventional hydrogel lenses (polymacon and etafilcon A) were placed in polypropylene lens cases filled with MPS containing 0.0001% PHMB and soaked for 6, 12, 24, 72, and 168 hours. After each interval, depleted MPS from lens cases were removed and assayed for activity against F. solani according to International Organization for Standardization (ISO) 14729 stand-alone procedure. A portion was aliquoted for chemical analysis.

corneal staining comparison
 
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Tested a PHMB solution
against Fusarium solani:

  • “Over time, the disinfectant uptake by some lenses can significantly reduce the PHMB concentration and the fungicidal activity of the MPS against F. solani."
  • "The results of our study demonstrate that consumers using PHMB-containing contact lens solution and exhibiting poor contact lens hygiene (such as reuse or extended soak times) may reduce the fungicidal activity of these MPSs."

Biocidal Efficacy of PHMB Against Staphylococcus aureus6†

Objectives: To determine the effect of 8 different lens materials on polyhexamethylene biguanide (PHMB) concentration in a tested multipurpose solution (MPS, 0.0001% PHMB, 6-hour soak) over time and to determine the effect of lenses on lens solution microbial efficacy over time.

Methods: Silicone hydrogel lenses and conventional hydrogel lenses were soaked in polypropylene lens cases filled with contact lens MPS containing 1 ppm PHMB for 6, 12, 24, 72, and 168 hours. Cases filled with the same solution without lenses were controls. After each time period, solutions from cases with the 8 types of lenses and controls were assayed for activity against Staphylococcus aureus according to International Organization for Standardization-14729 with modifications. Solutions were analyzed for PHMB concentration at each time point.

corneal staining comparison
 
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Tested a PHMB solution
against Staphylococcus aureus:

  • "Etailcon A lenses reduced the PHMB levels in the solution within the recommended 6-hour disinfection time, and the biocidal efficacy was greatly reduced.”
  • "The efficacy of MPS was affected by some lens materials and PHMB concentration. Lens materials differ in their effect on PHMB concentration and the subsequent efficacy of the MPS. Over time, some lens materials can significantly reduce the PHMB concentration and the MPS’s microbial activity against S. aureus."
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Alcon Vision Care is uniquely poised to serve every contact lens wearer by addressing the full life cycle of their needs.