#1 selling preservative-free dry eye drop brand in Canada1
Advanced hydration for longer-lasting relief compared to HA alone2
Safe for use with soft contact lenses3*
HA = hyaluronic acid.
* Not a rewetting solution.
Hyaluronic acid: A component of our formulation for advanced hydration4,5*
Systane® HYDRATION contains HA as the sodium salt to hydrate dry eyes.4,5*
Hydroxypropyl-guar: The key to prolonged protection and hydration retention6
HP-guar is derived from guar gum and forms a viscous solution at low concentrations.7
A clinically proven dual-polymer formula of HA + HP-guar8
On the eye, Systane® HYDRATION becomes elastic and spreads over the surface of the cornea. The HA/HP-guar matrix adheres to the mucin layer of the tear film as well as the cells in the epithelium. This unique chemistry creates a moisture layer that provides increased hydration.4,9*†
* In vitro data.
† In a mouse cornea model.
Systane® HYDRATION relieves dry eye symptoms for a better quality of life10
A powerful combination of ingredients proven to offer long-lasting hydration protection and relief for those suffering from moderate, chronic dry eye.2,4,5*
* In vitro data.
Effective hydration | Provided longer-lasting relief vs formulations containing only HA2,4*
A unique formula proven to deliver 2x greater moisture retention compared to HA alone4*
* In vitro study.
The dual-polymer formula is 2x more lubricious than formulations with HA alone4*
* In vitro data.
Repair effect | Significantly improved the rate of corneal healing vs other leading HA-containing drops9*
* In a mouse cornea model. † Trademarks are the property of their respective owner. Na-Fl = sodium fluorescein.
Post-surgery efficacy | Systane® ULTRA with HP-guar demonstrated 2X greater symptom improvement in post-surgical patients vs standard of care11*
Systane® HYDRATION builds on Systane® ULTRA’s formulation and contains hyaluronic acid for enhanced hydration.
* OSDI = Ocular Surface Disease Index. * A study performed with Systane® ULTRA.
Comfort and stability | Eye comfort before, during, and end of digital device use improved with Systane® HYDRATION12
After two weeks of use, Systane® HYDRATION Preservative-Free improved dry eye comfort and quality of life of digital device users12*
Systane® HYDRATION provides a more stable tear film vs 0.1% HA and 0.2% HA-only formulations13†
* End of the day comfort: Visual analogue scale score changes from 56.9 ± 21.5 (day 1) vs 74.9 ± 19.3 (week 2). Based on a survey on impact of dry eye on daily life from baseline vs week 2. N=30. p<0.0001 for all. Dosing: Participants on average applied their drops 4.4 ± 0.8, 5.0 ± 1.5, and 5.1 ± 1.4 times per day on the first day, at 1 week, and at 2 weeks, respectively.
† Tear breakup time for 0.15% HA-HPG vs 0.2% HA and 0.1% HA eye drops (10.3 ± 6.5 vs 7.7 ± 3.6 and 7.3 ± 4.1; post hoc p=0.01 and p=0.003, respectively).
Explore the rest of the
SYSTANE® portfolio
Important safety information
TO BE SURE THIS PRODUCT IS RIGHT FOR YOUR PATIENTS, ALWAYS READ AND FOLLOW THE LABEL.
References:
1. Alcon. Data on File. 2024.
2. Rolando M, Autori S, Badino F, Barabino S. Protecting the ocular surface and improving the quality of life of dry eye patients: a study of the efficacy of an hp-guar containing ocular lubricant in a population of dry eye patients. J Ocul Pharmacol Ther. 2009;25(3):271-278.
3. Alcon. Data on File. 2015.
4. Rangarajan R, et al. Effects of a hyaluronic acid/hydroxypropyl guar artificial tear solution on protection, recovery, and lubricity in models of corneal epithelium. J Ocul Pharmacol Ther. 2015;31(8):491-497.
5. Davitt WF, Bloomenstein M, Christensen M, Martin AE. Efficacy in patients with dry eye after treatment with a new lubricant eye drop formulation. J Ocul Pharmacol Ther. 2010;26(4):347-353.
6. Srinivasan S, Manoj V. A decade of effective dry eye disease management with Systane ultra (polyethylene glycol/propylene glycol with hydroxypropyl guar) lubricant eye drops. Clin Ophthalmol. 2021;15:2421-2435.
7. Petricek I, et al. Hydroxypropyl-guar gellable lubricant eye drops for dry eye treatment. Expert Opin Pharmacother. 2008;9(8):1431-1436.
8. Labetoulle M, et al. Efficacy and safety of dual-polymer hydroxypropyl guar- and hyaluronic acid-containing lubricant eyedrops for the management of dry-eye disease: a randomized double-masked clinical study. Clin Ophthalmol. 2018;12:2499-2508.
9. Carlson E, et al. Impact of hyaluronic acid-containing artificial tear products on reepithelialization in an in vivo corneal wound model. J Ocul Pharmacol Ther. 2018;34(4):360-364.
10. Mrukwa-Kominek E, et al. First Clinical Reports on the Application of the Modern Dual-Polymer Formula in Aqueous Deficiency Dry Eye Syndrome - Polish Observations. Presented at the 20th European Society of Cataract and Refractive Surgery (ESCRS) Winter Meeting. February 26-28, 2016.
11. Davidson R, Schultz-Scott B. Efficacy Evaluation of SYSTANE® ULTRA in Patients with Dry Eye Undergoing Cataract Surgery. Poster presented at: 30th Congress of the European Society of Cataract and Refractive Surgeons; September 8-12, 2012; Milan, Italy.
12. Pucker AD, et al. Quality of life in digital device users who are treated with Systane hydration PF. Clin Optom. 2023;15:45-54.
13. Jia T, et al. Comparison of eye drop retention time using fluorophotometry in three commercially available lubricant eye drops. Optoms Vis Sci. 2024;101:603-607.
©2026 Alcon Inc. CA-SYH-2600004
