In a recent study, it has been shown that when oxidized glutathione (GSSG) in BSS PLUS® Irrigating Solution is used for vitrectomy, the GSSG is converted to reduced glutathione (GSH) in the retina. The glutathione from BSS PLUS® Irrigating Solution ultimately is incorporated into the intracellular glutathione pool.1
Additionally, it has been shown that BSS PLUS® Irrigating Solution is less harmful than GSSG-free solutions to the barrier function of the RPE cells, and the GSSG has a beneficial effect in maintaining the functions of the RPE.2
Diabetic retinopathy results when abnormal changes take place in the blood vessels of the retina. In many patients, retinal blood vessels may swell and hemorrhage, where in others abnormal new blood vessels grow on the surface of the retina. BSS PLUS® Irrigating Solution has been shown to help fight the oxidative effects of free-radical formation during surgery. Recent studies have shown that the retina and choroid can benefit from supplemental glutathione found in BSS PLUS® Irrigating Solution.3
Restoration of normal vision, or the prevention of continued visual loss, can now be accomplished in more advanced or difficult vitreoretinal conditions. Macular holes and proliferative vitreoretinopathy are common and visually debilitating conditions.
In proliferative vitreoretinopathy, the retina develops fixed folds secondary to the formation of taut vitreal and pre-retinal fibrous membranes. This severe distortion of the retina often results in a complicated retinal detachment. In macular hole conditions, the retina develops a hole in the macular region. These disease states are accompanied by dramatic visual loss and lengthy, complicated surgeries. BSS PLUS® Irrigating Solution protects the ocular tissues that have been exposed to the atmosphere, microscope light and metabolic stress from free-radical formation.